![]() In African countries, a large proportion of the population depends solely on herbal medicines for their primary health care needs. An evaluation of acute and subchronic toxicities of a Nigerian polyherbal tea remedy. Ogbonnia SO, Mbaka GO, Anyika EN, Emordi JE, Nwakakwa N. Presently, there is a revitalization of interest in the use of medicinal plants by over 80% of the world population ( Ogbonnia et al., 2011 21. An evaluation of acute and subchronic toxicities of a Nigerian polyherbal antidiabetic remedy. ![]() Obi H, Ilodigwe EE, Ajaghaku DL, Okonta JM. Medicinal plants are the richest alternative bio-resources to synthetic drugs ( Obi et al., 2012 19. ![]() The leaf extract of Dryopteris filix-mas may be hepatotoxic and nephrotoxic when used for long periods.ĭryopteris filix mas Leaf Extract Sub-chronic toxicity Acute toxicity Nephrotoxicity Hepatotoxicity Dryopteris/toxicity Toxicity tests/utilization Ethanol/ toxicity. However, toxicities observed on 91 st day were reversible in recovery studies. There was significant (p<0.005) reduction in white blood cell and lymphocyte counts, significant (p<0.05) increase in some liver and kidney biomarkers as well as alterations in liver and kidney histo-architecture on 91 st days in animals that were treated with 250 and 500 mg/kg extract. Acute toxicity test did not show toxicity or death at 5000 mg/kg. Phytochemical screening revealed the presence of tannins, phenols, flavonoids, saponins, steroids, alkaloids, terpenoids, reducing sugar and cardiac glycosides. Also, a 28 day recovery study was carried out to determine reversibility in toxicological effects. Liver and kidneys were harvested for histopathology analyses on 91 st day. Blood samples were collected via retro-orbital puncture for baseline studies and at 31, 61 and 91 st days for determination of hematological, kidney and liver function parameters. In sub-chronic toxicity test, animals were treated with 62.5, 125, 250 and 500 mg/kg of extract every day for 90 days. Acute toxicity and phytochemical tests on ethanol leaf extract were determined. This study evaluated the acute and sub-chronic toxicities of ethanol leaf extract of Dryopteris filix-mas.
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